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Hydrocortistab injection contains the active ingredient hydrocortisone acetate, which is a type of medicine known as a corticosteroid. Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many important functions in the body, including control of inflammatory responses. Corticosteroid medicines are man-made derivatives of the natural hormones. They are often simply called steroids, but it should be noted that they are very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders.
Hydrocortisone is a synthetic steroid that has an anti-inflammatory effect. It is used to decrease inflammation in various different diseases and conditions.
Hydrocortisone works by acting within cells to prevent the release of certain chemicals that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses, resulting in inflammation. By decreasing the release of these chemicals in a particular area, inflammation is reduced. This can help control a wide number of disease states characterised by excessive inflammation. These include inflammation of the joints in arthritis.
Hydrocortistab injection is administered directly into inflamed joints, or inflamed soft tissue, in conditions such as arthritis or tenosynovitis, to decrease inflammation and pain in that particular area and increase mobility of the affected joint.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The principal side effects following injection into or around a joint are a temporary increase in pain and swelling.
In some circumstances, particularly after high or prolonged local dosage, the medicine may be absorbed into the bloodstream in amounts sufficient to produce effects on other parts of the body, such as those listed below (systemic effects).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while being treated with this one, to ensure that the combination is safe.
In some circumstances, particularly after high or prolonged local dosage, the medicine may be absorbed into the bloodstream in amounts sufficient to affect other medicines, such as those listed below.
Hydrocortisone can cause fluid and salt retention and so may oppose the effects of the following medicines:
Hydrocortisone may increase blood sugar levels and so may oppose the blood sugar lowering effects of antidiabetic medicines. People with diabetes may need an increase in their dose of insulin or antidiabetic tablets.
There may be an increased chance of the level of potassium in the blood falling too low (hypokalaemia) if hydrocortisone is used in combination with any of the following medicines, which can also lower the amount of potassium in the blood:
If the level of potassium in your blood falls during treatment, this can increase the risk of side effects on the heart caused by a medicine called digoxin.
Hydrocortisone may enhance the anti-blood-clotting effect of anticoagulant medicines such as warfarin. People taking anticoagulant medicines in combination with hydrocortisone should have their blood clotting time (INR) regularly monitored, particularly after starting or stopping treatment with hydrocortisone and after any dose changes.
If hydrocortisone is used in combination with non-steroidal anti-inflammatory drugs (NSAIDs) eg ibuprofen, there may be an increased risk of side effects on the gut, such as stomach ulceration and bleeding.
Hydrocortisone may decrease the blood levels of salicylates such as aspirin. When hydrocortisone is stopped, this may result in excessive levels of the salicylate, unless the dose is readjusted.
The following medicines may increase the removal of hydrocortisone from the body, thus reducing its effects. You may need a larger dose of hydrocortisone if you are also taking any of these medicines:
The effect of corticosteroids may be reduced in the three to four days following use of mifepristone.
The following medicines may reduce the removal of hydrocortisone from the body and so may increase its effects or side effects:
Hydrocortisone may decrease the body's immune response. This means that vaccines may be less effective if given during treatment, because the body does not produce sufficient antibodies. Live vaccines may cause serious infections. Live vaccines include: measles, mumps, rubella, MMR, BCG, chickenpox, oral polio, oral typhoid and yellow fever. These should not be given to people whose immune system is underactive due to treatment with this medicine.
Hydrocortisone has many different uses and comes in many different forms. The factsheets below contain information about hydrocortisone used in various areas of the body.
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Last updated 20.06.2008