
THURSDAY, Feb. 16 -- Researchers have sequenced the genomes of the animal known as the Tasmanian devil and the transmissible facial cancer that threatens the species with extinction.
The findings may help efforts to save the meat-eating marsupials found only on the Australian island of Tasmania, according to the study in the Feb. 17 issue of the journal Cell.
"There are targeted drugs that work against cancer genes," Elizabeth Murchison, a Tasmanian native working at the Wellcome Trust Sanger Institute in the United Kingdom, said in a journal news release "We hope some of the mutations that we have found in genes in the devil cancer may point to therapeutic strategies."
The facial cancer ravaging the Tasmanian devil population is spread through bites that transfer living cancer cells. Tasmanian devils bite each other often. The first recorded case of the disease was noted in 1996. By the early 2000s, "it was clear that this was a new type of infectious disease," Murchison said.
The genomes of the Tasmanian devil and the facial cancer suggest that the cancer first arose in a female Tasmanian devil.
"The cancer genome has evolved as it has spread through the population, but overall it appears to be rather stable," study senior author Michael Stratton said in the news release. "The genetic differences between 104 Tasmanian devil tumors from all around the island present us with a remarkably clear picture of how the cancer has spread in time and space over the last couple of decades, which may help with strategies for disease containment."
More than 17,000 mutations in the devils' cancer genome have been cataloged and researchers must now determine which of those are most important. Early indications suggest that changes in immunity genes may explain how the cancer evades the immune system.
-- Robert Preidt
SOURCE: Cell, news release, Feb. 13, 2012


WEDNESDAY, Feb. 15 -- Scientists have long believed that urinary tract infections are typically caused by a person's own E. coli bacteria, but a new Canadian study suggests the bacteria may more often than not come from chickens.
Yes, chickens.
As many as 85 percent of urinary tract infections are caused by E. coli, according to the report in the March issue of Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.
Researchers compared the genetic fingerprints of E. coli from these infections to that of E. coli from chicken, beef and pork. And they found a match: chicken. What's more, they report that the infections probably came directly from the chickens, not from human contamination during food processing.
"Chicken may be a reservoir for the E. coli that cause infections like urinary tract infections," said study author Amee Manges, who is with the department of epidemiology, biostatistics and occupational health at McGill University in Montreal.
"We are also concerned about the selection and amplification of drug-resistant E. coli on the farms because of improper or overuse of antimicrobials during food animal production. It may be possible to reduce the level of drug-resistant infections in humans by encouraging rational and judicious use of antimicrobials on farms," Manges said.
"We just want to emphasize that it isn't just inappropriate use of antibiotics in human medicine that matters, but also the use of antibiotics in veterinary medicine and food production that leads to greater drug-resistant bugs," the study author added.
The U.S. Food and Drug Administration already advises against the overuse of antibiotics in livestock, because it can lead to resistant strains of bacteria.
Dr. Philip Tierno, director of clinical microbiology and immunology at NYU Langone Medical Center in New York City, said it is not surprising that the food supply, especially chicken, may play a role in causing urinary tract and other infections. He said the best protection begins with proper hygiene.
"If you practice good personal hygiene, good food hygiene and good home hygiene, we can reduce the number of infections," he suggested. Proper hand washing should last for 20 seconds. "Wash in between your [fingers] and under your nails," Tierno said. "When dealing with counter surfaces, use a product that can disinfect surfaces and prevent cross-contamination."
Cooking also helps kill disease-causing bugs. "Eat nothing raw. Cook it well, and if you are eating vegetables, make sure to soak them and wash them well," he said.
The solution is definitely not to throw more antibiotics at livestock, Tierno agreed. As far as preventing E. coli in chicken coops, "we need a better system developed to raise chickens so they are not raised in crowded conditions and prone to diseases like E. coli," he explained.
Good hygiene is never a bad idea, but the truth is that E. coli is everywhere, said Dr. Elizabeth Kavaler, a urologist at Lenox Hill Hospital in New York City. "The best defense against urinary tract infections is to exercise, eat well and get proper sleep so your immune system is strong and can fend off what you can't see, including E. coli," she said. "Be healthy, wash your hands, take care of yourself and when you have a urinary tract infection, see your doctor for an antibiotic to treat it."
SOURCES: Amee Manges, Ph.D., M.P.H., department of epidemiology, biostatistics and occupational health, McGill University, Montreal; Philip Tierno, Ph.D., director, clinical microbiology and immunology, NYU Langone Medical Center, New York City; Elizabeth Kavaler, M.D., urologist, Lenox Hill Hospital, New York City; Feb. 15, 2012, Emerging Infectious Diseases, online



New Rankings Uncover Toxic Chemicals in Top 10 Unhealthy Car Interiors
By Jennifer Warner
WebMD Health News
Reviewed by Laura J. Martin, MD
Feb. 15, 2012 -- That "new car smell" may come from toxic chemicals, according to new research.
A new study suggests that new car smell comes from toxic chemicals off-gassing in a car's interior, like brominated flame retardants (BFRs), chromium, and lead. In all, researchers identified more than 275 different chemicals in vehicle interiors, including those associated with birth defects, impaired learning, liver problems, and cancer.
The 2012 new vehicle study from the nonprofit Ecology Center analyzed the chemical content of more than 200 new cars for its top 10 healthy and unhealthy car interiors. The higher the vehicle rating in the study, the higher the level of these chemicals was, based on their testing methods.
At the top of the list for the most healthy car interior is the 2012 Honda Civic. Researchers say it earned strong marks for not having any bromine-based flame retardants, while boasting polyvinyl chloride (PVC)-free interior fabrics and trim, and low levels of heavy metals.
At the bottom of the list are the 2011 Mitsubishi Outlander Sport and 2011 Chrysler 200 SC, which both had scores in the "high" range. For example, the Mitsubishi Outlander had bromine and antimony-based flame retardants in seating and other areas, chromium-treated leather, and lead in seating materials.
Year | Make | Model | Vehicle Rating |
2012 | Honda | Civic | 0.46 |
2011 | Toyota | Prius | 0.55 |
2011 | Honda | CR-Z | 0.63 |
2011 | Nissan | Cube | 0.65 |
2012 | Acura | RDX | 0.74 |
2012 | Acura | ZDX | 0.74 |
2012 | Audi | S5 | 0.74 |
2011 | Smart | Coupe | 0.74 |
2011 | Toyota | Venza | 0.77 |
2011 | Smart | Passion | 0.79 |
(Worst at bottom)
| Year | Make | Model | Vehicle Rating |
2012 | Mini Cooper | S. Clubman | 2.84 |
2012 | VW | Eos | 2.85 |
2011 | Kia | Sportage | 2.87 |
2011 | Chevy | Aveo5 | 2.89 |
2012 | Hyundai | Accent | 2.98 |
2011 | Mazda | CX-7 | 3.08 |
2011 | Nissan | Versa | 3.08 |
2011 | Kia | Soul | 3.11 |
2011 | Chrysler | 200 SC | 3.17 |
2011 | Mitsubishi | Outlander Sport | 3.17 |
Researchers say that immediately after delivery, new cars have unusually high concentrations of a variety of chemicals, hence that "new car smell."
In their study, the interiors of more than 200 cars from the 2011-2012 model year were analyzed using a portable X-ray Fluorescence (XRF) analyzer. The analyzer detects chemical elements such as lead, cadmium, chlorine, arsenic, mercury, tin, and antimony.
Common areas checked in the car interiors were seats, arm rests, steering wheels, door trim, and shift knobs, among others.
Researchers say the elemental composition of the materials reveals the presence of potentially hazardous chemicals, such as BFRs, PVC, and possibly phthalate plastics. They say car interiors are like chemical reactors, with temperatures reaching extremes of up to 192 F. These high temperatures can increase the concentration of volatile compounds in the car and speed the breakdown of materials.
Exposure to toxic chemicals can be high indoors and in enclosed spaces like a car interior. Drivers are exposed to these chemicals by breathing and contact with dust.
The EPA says indoor air pollution is one of the top environmental threats to public health, since Americans spend 90% of their time indoors. Next to homes and offices, Americans spend the most time in automobiles, an average of one-and-a-half hours per day.
Overall, researchers say vehicle ratings are improving thanks to the reduction in the use of PVC and bromine-based flame retardants by some automakers.
They say the top-rated automaker for healthy interiors in 2012 was Honda and has been since it started testing in 2007. Hyundai-Kia has been the lowest-ranked manufacturer for the last two years.
German automaker VW, along with Mitsubishi and Ford, earned the title of most-improved automakers. Their scores improved by 30% to 42% from the 2009-2010 model year to the 2011-2012 model year.
Daimler AG and Volvo were the only two automakers with declining average scores, -29% and -13%, respectively.
For a complete list of ratings, see www.HealthyStuff.org.
SOURCES: Ecology Center, 2012 New Vehicle Study.News release, HealthyStuff.org.